Fish and seafood are rich in many nutrients, including proteins, amino acids, vitamins, and omega-3 essential fatty acids. Fish are also a rich source of calcium, phosphorus, iron, zinc, potassium, sodium, and iodine. Hence, this study aims to assess the macroelement (Na, K, Ca, Mg, and P) content of liver and muscle in the wild and farmed Capoeta damascina and its beneficial health for the local consumer. Macroelements were investigated in the farmed and wild fish (C. damascina) from Armand River in Chaharmahal-va-Bakhtiari province, Iran, by inductively coupled plasma-optical emission spectrometry (ICP-OES). Also, Daily Value % for all macroelements was assessed. Potassium was the most abundant macroelement in tissues of both fish species, whereas sodium was the lowest. There was a significant difference between calcium, magnesium, and potassium in comparing elements content between liver and muscle. However, there was no significant difference in the phosphorus and sodium content. The calcium content of farmed tissues was higher than wild tissues. However, it was not any significant difference in levels of phosphorus, magnesium, potassium, and sodium between wild and farmed fish. Also, both wild and farmed fish were excellent sources of phosphorus and good sources of magnesium. Both farmed and wild fish muscle are good sources for phosphorous and magnesium that may reach beneficial health for the local consumers. Farming of C. damascina suggested to less capturing of wild C. damascina for reserving the ecosystem.