Document Type : Review Article
1 Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch. Islamic Azad University, Tehran, Iran.
Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In the present study, we summarized the potential mechanisms of the effect of Fiestin on CRC. Electronic literature searches were conducted on Medline, Web of Science, and Google Scholar until March 2020. Our search was supplemented with the search of publisher databases like Elsevier and Springer. The search was conducted with “Fiestin” in combination with the following keywords: Colorectal Neoplasms, Colon, Rectum, Apoptosis, Inflammation, and “Precancerous Lesions” among humans, animal, and in-vitro studies. 14 articles during 2005 and 2018 assessed the effect of Fiestin on CRC. One was RCT, 3 of them were animal studies and 10 papers were performed on cell culture. Our Findings suggested that Fiestin may have positive effects on cancer cells due to its anti-inflammatory, apoptotic, anti-oxidative, and cell cycle modifying properties. According to the literature, it seems that Fiestin induces cell cycle arrest and suppresses cellular growth by modulating through some signaling pathways like inhibition of CDKs and Fiestin decreases protein levels of cell division cycles like CDC 2 and CDC25C. Fiestin may also induce cell apoptosis cascades such as activation of caspase 3, 7, and cleavage of procaspase 3 and inhibition of caspase 8. Fiestin also may have anti-inflammatory effects by inhibiting PGE2 production and expression of COX2. Additionally, it may have some anti-oxidant effects by reducing some tumor markers and enhancement levels of some anti-oxidants agents.
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