Document Type : Review Article


1 Department of Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran


An array of age-related diseases (like diabetes mellitus type 2, cardiovascular disease, Alzheimer's, osteoporosis, cancer, hypertension, atherosclerosis, and arthritis), which are originated from low-grade, chronic, sterile inflammation, called inflammaging have been increased in aged population. In line with this notion, an abundant body of evidence has been demonstrated that quasi-self-stimulations like over-nutrition and gut microbiota could produce metabolic induced inflammation called meta-inflammation. In fact, meta-inflammation which is a result of nutrient excess is a special situation of inflammaging that has a similar molecular mechanism to inflammaging and both inflammaging and meta-inflammation resulted in activating pro-inflammatory pathway. Today it has been revealed that the human diet has significant impacts on preventing meta-inflammation.  As a matter of fact, nutrition is one of the most pivotal modulators of low grade- chronic inflammation which can control it. Expanding data showed that phytochemicals especially curcumin and resveratrol, melatonin and vitamin D may exert several anti-inflammatory activities in the context of meta-inflammation. Since these nutrients have pleiotropic functions for inhibiting metabolic inflammation, they could be more efficient in anti-inflammatory based therapy for meta-inflammation in comparison to other nutrients. Here we reviewed the anti-inflammatory and immuno-modulatory effects of some nutrients with pleiotropic effects on inflammation by considering their impacts on the meta-inflammination.


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