Document Type : Original Article
1 Department of Food Science and Technology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
2 Department of Food Safety and Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Department of Food Quality Control and Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran
Biodegradable polymeric nanoparticles have been extensively used as colloidal materials for nanoparticles production designed for various purposes, including drug targeting, enhancement of drug bioavailability and protection of drug bioactivity and stability. In particular, poly (lactide‐co‐glycolide) (PLGA) as a polyester has been FDA approved for human use. In this research, the biodegradable polymeric nanoparticle of casein/poly lactic-co-glycolic acid (PLGA) containing three concentrations of alpha-tocopherol was prepared. The comparative evaluation of these nanoparticles, including morphology, size, zeta potential, entrapment rate, spectroscopy, thermal resistance, and their release profile was carried out. The comparative results suggested that the sizes of derived nanoparticles were between 150 and 350 nanometers. In addition, there was a significant difference between the nanoparticles size and increase in alpha-tocopherol percentage used in this formulation (p<0.05). The accumulated results indicated that the highest entrapment rate belonged to 10 percent of alpha-tocopherol, and higher concentrations decrease the entrapment rate. The using of casein/PLGA can be optimized the characteristics and morphological properties of nanoparticles. The polymeric nanoparticles containing alpha-tocopherol can be used as a biologic preservative to improve drug delivery and consumer health.
- Wakeel A, Farooq M, Bashir K, Ozturk L. Micronutrient Malnutrition and Biofortification: Recent advances and future perspectives. Plant Micronutrient Use Efficiency: Elsevier; 2018. p. 225-43.
- Alenisan MA, Alqattan HH, Tolbah LS, Shori ABJ. Antioxidant properties of dairy products fortified with natural additives: A review. Journal of the Association of Arab Universities for Basic and Applied Sciences. 2017;24(1):101-6.
- Wagner K-H, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol–an underestimated vitamin? Annals of Nutrition and Metabolism. 2004;48(3):169-88.
- Quintero C, Vera R, Perez LD. α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties. Polímeros. 2016;26(4):304-12.
- Farias MC, Moura ML, Andrade L, Leão MHMR. Encapsulation of the alpha-tocopherol in a glassy food model matrix. Materials Research. 2007;10(1):57-62.
- Hategekimana J, Masamba KG, Ma J, Zhong F. Encapsulation of vitamin E: effect of physicochemical properties of wall material on retention and stability. Carbohydrate Polymers. 2015;124:172-9.
- Trombino S, Cassano R, Muzzalupo R, Pingitore A, Cione E, Picci NJC, et al. Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and α-tocopherol. Colloids and Surfaces B: Biointerfaces. 2009;72(2):181-7.
- Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles-based drug delivery systems. Colloids and Surfaces B: Biointerfaces. 2010;75(1):1-18.
- Gentile P, Chiono V, Carmagnola I, Hatton PJ. An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. International Journal of Molecular Sciences. 2014;15(3):3640-59.
- Elzoghby AO, El-Fotoh WSA, Elgindy NAJ. Casein-based formulations as promising controlled release drug delivery systems. Journal of Controlled Release. 2011;153(3):206-16.
- Narayanan S, Pavithran M, Viswanath A, Narayanan D, Mohan CC, Manzoor K, et al. Sequentially releasing dual-drug-loaded PLGA–casein core/shell nanomedicine: Design, synthesis, biocompatibility and pharmacokinetics. Acta Biomaterialia. 2014;10(5):2112-24.
- Jawahar N, Venkatesh DN, Sureshkumar R, Senthil V, Ganesh G, Vinoth P, et al. Development and characterization of PLGA-nanoparticles containing carvedilol. Journal of Pharmaceutical Sciences and Research. 2009;1:123-8.
- Sourabhan S, Kaladhar K, Sharma C. Method to enhance the encapsulation of biologically active molecules in PLGA nanoparticles. Trends Biomater Artif Organs. 2009;22(3):211-5.
- Zohri M, Alavidjeh MS, Haririan I, Ardestani MS, Ebrahimi SES, Sani HT, et al. A comparative study between the antibacterial effect of nisin and nisin-loaded chitosan/alginate nanoparticles on the growth of Staphylococcus aureus in raw and pasteurized milk samples. Probiotics and Antimicrobial Proteins. 2010;2(4):258-66.
- Gazori T, Khoshayand MR, Azizi E, Yazdizade P, Nomani A, Haririan I. Evaluation of alginate/chitosan nanoparticles as antisense delivery vector: formulation, optimization and in vitro characterization. Carbohydrate Polymers. 2009;77(3):599-606.
- Saptarshi SR, Duschl A, Lopata ALJ. Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle. Journal of Nanobiotechnology 2013;11(1):26.
- Luo Y, Zhang B, Whent M, Yu LL, Wang Q. Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study. Colloids and Surfaces B: Biointerfaces. 2011;85(2):145-52.
- Harmata A, Guelcher S. Effects of surface modification on polymeric biocomposites for orthopedic applications. Nanocomposites for Musculoskeletal Tissue Regeneration: Elsevier; 2016. p. 67-91.
- Jurkiewicz P, Cwiklik L, Vojtíšková A, Jungwirth P, Hof M. Structure, dynamics, and hydration of POPC/POPS bilayers suspended in NaCl, KCl, and CsCl solutions. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2012;1818(3):609-16.
- Harnsilawat T, Pongsawatmanit R, McClements D. Characterization of β-lactoglobulin–sodium alginate interactions in aqueous solutions: A calorimetry, light scattering, electrophoretic mobility and solubility study. Food Hydrocolloids. 2006;20(5):577-85.
- Zambrano-Zaragoza M, Mercado-Silva E, Gutiérrez-Cortez E, Cornejo-Villegas M, Quintanar-Guerrero D. The effect of nano-coatings with α-tocopherol and xanthan gum on shelf-life and browning index of fresh-cut “Red Delicious” apples. Innovative Food Science & Emerging Technologies 2014;22:188-96.
- Huang CL, Steele TW, Widjaja E, Boey FY, Venkatraman SS, Loo JS. The influence of additives in modulating drug delivery and degradation of PLGA thin films. NPG Asia Materials 2013;5(7):e54.
- Pool H, Quintanar D, de Dios Figueroa J, Mano CM, Bechara JEH, Godínez LA, et al. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles. Journal of Nanomaterials. 2012;2012:86.