Fakhradin Hassanlouei; Seyed Ali Hoseini; Laleh Behbudi Tabrizi; Masod Haji Rasouli
Volume 3, Issue 1 , March 2020, , Pages 6-10
Abstract
Alzheimer's disease is an age-related ailment that affects more and more people every day. It is a type of amnesia with brain dysfunction that gradually degrades the patient's mental abilities. The aim of the present study was to investigate the effect of endurance training with royal jelly consumption ...
Read More
Alzheimer's disease is an age-related ailment that affects more and more people every day. It is a type of amnesia with brain dysfunction that gradually degrades the patient's mental abilities. The aim of the present study was to investigate the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer's rats treated with trimethyltin. In this experimental study, 30 rats underwent intraperitoneal injection of 8 mg/kg trimethyltin (TMT) chloride and after ensuring Alzheimer's disease were divided into groups of 6 subjects: control, training, royal jelly consumption, and training with royal jelly consumption. In order to investigate the effects of Alzheimer's induction on dopamine levels, 6 rats were included in the healthy control group. The training groups ran on the treadmill for eight weeks, five sessions a week, and 60 minutes each session. The royal jelly consumption groups received 100 mg/kg royal jelly per day peritoneally for eight weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s mean comparison tests were used to analyze the findings (p≤0.05). Alzheimer's induction with trimethyltin toxin had a significant effect on reducing dopamine gene expression levels (p=0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (p=0.001). Also, training and training with royal jelly consumption had a greater effect on increasing dopamine gene expression levels than royal jelly consumption (p=0.001). Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer's disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone.
Zahra Jalili; Reza Tavakoli; Sahar Jalili
Volume 2, Issue 2 , November 2019, , Pages 1-5
Abstract
Alzheimer's disease (AD) is the most common of dementia characterized by the gradual decrease of mental ability and behavioral disorders. AD threatens the health of 5%-10% of people over 65 years old. Studies have also suggested the consumption containing omega-3 fatty acids (EPA, DHA) may be a strategy ...
Read More
Alzheimer's disease (AD) is the most common of dementia characterized by the gradual decrease of mental ability and behavioral disorders. AD threatens the health of 5%-10% of people over 65 years old. Studies have also suggested the consumption containing omega-3 fatty acids (EPA, DHA) may be a strategy to prevent the disease. The current study aimed at determining the predictors of the omega-3 supplementation to prevent AD based on constructs of Health Belief Model in the elderly. In the current cross-sectional study, 333 elderly patients referring to health centers in Tehran from 2015 to 2016 were selected by the stratified random sampling method. The inclusion criteria were age over 60 years old without AD and signing the informed consent form. Data were collected by a questionnaire developed based on Health Belief Model constructs after determining its validity and reliability. The collected data were analyzed by using SPSS-18 software and statistical tests, including logistic regression analysis, Chi-square, and independent-samples t-tests. The highest calculated mean belonged to the perceived susceptibility construct (%40.4) followed by knowledge (%30.6). The mean omega-3 consumption among the samples was (%27.6.) The lowest mean belonged to the perceived barriers construct indicating that the construct cannot be an obstacle to consume omega-3 supplementation. According to the results of the current study and the mean omega-3 consumption at low and the moderate levels of knowledge in the elderly, it was suggested to design and implement educational interventions based on the Health Belief Model for the elderly in order to prevent AD.
