Jafar Aldaghi; Ariyo Movahedi
Volume 4, Issue 1 , March 2021, , Pages 10-16
Abstract
One of the most worldwide chronic diseases is diabetes which has affected a large population worldwide and it is predicted that 649 million adults will be diabetic by 2040. Many foods and ingredients were tested to combat diabetes. Both probiotics and prebiotics which are known as synbiotic have shown ...
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One of the most worldwide chronic diseases is diabetes which has affected a large population worldwide and it is predicted that 649 million adults will be diabetic by 2040. Many foods and ingredients were tested to combat diabetes. Both probiotics and prebiotics which are known as synbiotic have shown beneficial effects on many diseases including diabetes. Although several studies have evaluated the effect of synbiotic consumption on lipid profile in patients with diabetes, findings are inconsistent. The aim of this study was to evaluate the effects of synbiotics on lipid profile in diabetic patients. A systematic literature search of online databases including PubMed, Scopus, Google Scholar, Magiran, SID, and Cochrane’s library was conducted up to January 2021. Randomized controlled trials (RCTs) investigating the effects of synbiotics on lipid profile in diabetic patients were included. A total of 11 RCTs with 662 participants were included. Synbiotic consumption resulted in a decrease in plasma concentrations of TC, TG, LDL, and an increase in plasma HDL levels compared to the control group (placebo supplements/control foods/conventional products). Synbiotic supplements may be profitable to ameliorate lipid profile in patients with diabetes and it should be suggested by both dietitians and healthcare clinics to diabetic patients.
Maryam Mohamadi Narab; Fereydoun Siassi; Fariba Koohdani
Volume 3, Issue 1 , March 2020, , Pages 28-34
Abstract
Diabetes mellitus and its comorbidities which result in dyslipidemia and cardiovascular diseases (CVD) are one of the leading causes of death in the world, and diet plays a major role in those disease incidences, especially through lipid oxidation mechanisms. This, in turn, leads to tissue inflammation ...
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Diabetes mellitus and its comorbidities which result in dyslipidemia and cardiovascular diseases (CVD) are one of the leading causes of death in the world, and diet plays a major role in those disease incidences, especially through lipid oxidation mechanisms. This, in turn, leads to tissue inflammation and the formation of atheromatous plaques. Our objective was to evaluate the association between the inflammatory potential of the diet and the incidence of dyslipidemia or its subclasses. We included 599 T2DM patients (276 men and 323 women), aged 35 to 65 years from diabetes referral centers, including Gabric Diabetes Association, Iranian Diabetes Society, and other health centers in Tehran. The lipid profiles in serum were measured by the dietary inflammatory index (DII) was computed using a validated 148-item semi-quantitative food frequency questionnaire (FFQ). The DII score ranged between - 4.85 and 5.46 and its mean and standard deviation (SD) was (-0.02±1.65). Younger individuals had higher adherence to the inflammatory diet (p≤0.001). Moreover, in the higher quartiles of DII, lower levels of physical activities were seen (p=0.005). There were no significant differences in the distribution of BMI, waist circumference, or lipid profile across DII quartiles. In the overall analysis, no significant association was observed between DII and lipid profile in the crude model, but after adjusting for confounders (age, gender, BMI, physical activity, and energy intake), the DII score was found to be positively associated with total cholesterol (β=3.123, SE=1.478, p=0.035) in all participants. A pro-inflammatory diet, as measured by a higher DII score, was prospectively associated with a higher level of total cholesterol in serum. This result may shed a light on the prevention of incidence dyslipidemia and CVD in diabetic patients by intervention in dietary patterns.
Raheleh Kamalzadeh Yazdi; Ghazaleh Shakeri; Motahareh Hatami Marbini; Behnood Abbasi
Volume 1, Issue 2 , June 2018, , Pages 29-34
Abstract
Diabetes is a progressive chronic disease and is considered as an important health problem, which has increased in recent years. The prevalence of diabetes in the Middle East in 2015 was 35.4 million, which more than 4.6 million people were in Iran. In this review, we specifically tried to summarize ...
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Diabetes is a progressive chronic disease and is considered as an important health problem, which has increased in recent years. The prevalence of diabetes in the Middle East in 2015 was 35.4 million, which more than 4.6 million people were in Iran. In this review, we specifically tried to summarize the results of clinical trials on the effects of selenium supplementation on glycemic control and lipid profile and inflammatory factors in type 2 diabetic patients. In this review, three interventional studies were included to evaluate the effect of Selenium supplementation on metabolic parameters. Serum insulin concentration and insulin resistance index were significantly reduced in two of the studies. Fasting plasma glucose and HDL cholesterol concentrations significantly increased in one study while in other studies no significant changes were observed. One of the studies showed a significant reduction in inflammatory Indicators and antioxidant capacity, one study also showed a significant decrease in lipid profiles. Selenium supplementation in patients with type 2 diabetes may have adverse effects on blood glucose homeostasis. However, it may improve lipid profile and antioxidant capacity and reduces inflammatory mediators in these patients. Therefore, in spite of the negative effects of glucose homeostasis with regard to the positive effects seen, further investigations are needed to evaluate the final effect of selenium supplementation in patients with type 2 diabetes.
