Mahtab Sotoudeh; Hafez Goudarzi; Behnood Abbasi
Abstract
Insulin resistance (IR) causes various metabolic disorders depending on the individual's genetic background. It can be detected up to 10-15 years before a person develops type 2 diabetes mellitus. The prevalence of diabetes is projected to increase from 8.4% in 2017 to 9.9% in 2045. ...
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Insulin resistance (IR) causes various metabolic disorders depending on the individual's genetic background. It can be detected up to 10-15 years before a person develops type 2 diabetes mellitus. The prevalence of diabetes is projected to increase from 8.4% in 2017 to 9.9% in 2045. Garlic has been used as herbal medicine. It has various biological effects such as anti-inflammatory, anti-diabetic, and antioxidants. The present study aims to investigate the impact of garlic on IR and other indices of glucose metabolism. Electronic databases including PubMed, Google Scholar, ScienceDirect, Science Information Database (SID), and publisher databases such as Elsevier, SpringerLink, and Wiley Online Library were searched till February 2022. Search terms involved “garlic” OR “Allium sativum” OR “alliin” OR “allicin” in combination with “fasting blood glucose” OR “fasting plasma glucose” OR “fasting blood sugar” OR “insulin resistance” OR “fasting insulin” OR “homeostasis assessment model” OR “HOMA” AND “polycystic ovary syndrome” OR “diabetes mellitus” OR “type 2 diabetes mellitus” OR “metabolic syndrome” OR “nonalcoholic fatty liver disease” OR “cardiovascular diseases”. After reviewing the databases mentioned seven articles were identified for this review. Totally, 459 participants including 228 women and 231 men, enrolled in the trials. Assessing the findings of these articles indicates that garlic has a positive effect on IR, plasma insulin, and fasting glucose. The hypoglycemic action of garlic is related to its sulfur-containing compounds which directly or indirectly stimulate insulin secretion. Also, allicin in garlic can combine with endogenous thiol-containing molecules which can release insulin from inactivation.
Navideh Khodadadi; Behnood Abbasi
Volume 3, Issue 2 , June 2020, , Pages 35-44
Abstract
Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In ...
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Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In the present study, we summarized the potential mechanisms of the effect of Fiestin on CRC. Electronic literature searches were conducted on Medline, Web of Science, and Google Scholar until March 2020. Our search was supplemented with the search of publisher databases like Elsevier and Springer. The search was conducted with “Fiestin” in combination with the following keywords: Colorectal Neoplasms, Colon, Rectum, Apoptosis, Inflammation, and “Precancerous Lesions” among humans, animal, and in-vitro studies. 14 articles during 2005 and 2018 assessed the effect of Fiestin on CRC. One was RCT, 3 of them were animal studies and 10 papers were performed on cell culture. Our Findings suggested that Fiestin may have positive effects on cancer cells due to its anti-inflammatory, apoptotic, anti-oxidative, and cell cycle modifying properties. According to the literature, it seems that Fiestin induces cell cycle arrest and suppresses cellular growth by modulating through some signaling pathways like inhibition of CDKs and Fiestin decreases protein levels of cell division cycles like CDC 2 and CDC25C. Fiestin may also induce cell apoptosis cascades such as activation of caspase 3, 7, and cleavage of procaspase 3 and inhibition of caspase 8. Fiestin also may have anti-inflammatory effects by inhibiting PGE2 production and expression of COX2. Additionally, it may have some anti-oxidant effects by reducing some tumor markers and enhancement levels of some anti-oxidants agents.
