Navideh Khodadadi; Behnood Abbasi
Volume 3, Issue 2 , June 2020, , Pages 35-44
Abstract
Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In ...
Read More
Colorectal cancer (CRC) is a virulent tumor rising in the interior wall of the large bowel. CRC is the third deadliest cancer globally and is the 4th common in Iran. Fiestin is a flavone that is present in some fruits and vegetables and is suggested to have beneficial effects on human cancer cells. In the present study, we summarized the potential mechanisms of the effect of Fiestin on CRC. Electronic literature searches were conducted on Medline, Web of Science, and Google Scholar until March 2020. Our search was supplemented with the search of publisher databases like Elsevier and Springer. The search was conducted with “Fiestin” in combination with the following keywords: Colorectal Neoplasms, Colon, Rectum, Apoptosis, Inflammation, and “Precancerous Lesions” among humans, animal, and in-vitro studies. 14 articles during 2005 and 2018 assessed the effect of Fiestin on CRC. One was RCT, 3 of them were animal studies and 10 papers were performed on cell culture. Our Findings suggested that Fiestin may have positive effects on cancer cells due to its anti-inflammatory, apoptotic, anti-oxidative, and cell cycle modifying properties. According to the literature, it seems that Fiestin induces cell cycle arrest and suppresses cellular growth by modulating through some signaling pathways like inhibition of CDKs and Fiestin decreases protein levels of cell division cycles like CDC 2 and CDC25C. Fiestin may also induce cell apoptosis cascades such as activation of caspase 3, 7, and cleavage of procaspase 3 and inhibition of caspase 8. Fiestin also may have anti-inflammatory effects by inhibiting PGE2 production and expression of COX2. Additionally, it may have some anti-oxidant effects by reducing some tumor markers and enhancement levels of some anti-oxidants agents.
Fatemeh Radkhouy; Samira Soltanieh; Shakiba Solgi; Maedeh Ansari; Behnood Abbasi
Volume 1, Issue 3 , September 2018, , Pages 39-47
Abstract
Colorectal cancer is the most common type of gastrointestinal cancer that results from abnormalities or changes in the genome and uncontrolled cell proliferation. Carnitine is a potent antioxidant that may result in an increase in cellular respiration, apoptosis, a reduction in proliferation and inflammation ...
Read More
Colorectal cancer is the most common type of gastrointestinal cancer that results from abnormalities or changes in the genome and uncontrolled cell proliferation. Carnitine is a potent antioxidant that may result in an increase in cellular respiration, apoptosis, a reduction in proliferation and inflammation of tumor cells by various mechanisms. The present study was conducted to summarize the effects of carnitine on the treatment or prevention of colorectal cancer. The review was conducted with the following words "L-carnitine" in combination with colorectal cancer, neoplasm, colon, rectum, apoptosis, inflammation and precancerous lesions among animal and in vitro studies. From six interventional studies investigated in this article, one of them was performed on two groups of mice having precancerous lesions and macroscopic colonic tumors divided into AOM and APC groups and five other studies on adenocarcinoma cell lines of NCOL-1, Caco-2, HT-29, and SW480. One of them also was performed on DMH-induced colon carcinogenesis mouse model. These studies reported significant increment in the amount of the fatty acid transportation into the mitochondria; generation of mitochondrial superoxide anions (O2-), apoptosis and cell death in cells which were exposed by L-carnitine. An increment was also observed in pro-apoptotic proteins Caspase, Bak and Bax and reduction in anti-apoptotic proteins Bcl-Xl. In these studies, cellular inflammation which was associated with products of the cyclooxygenase enzyme pathway, and cancer cell proliferation was reduced as well and there was an increment in DNA fragmentation. The aberrant crypt foci development and pre-cancerous lesions were significantly inhibited by carnitine in the colons of the studied mice but did not exert protective effects on their intestinal tumors. L-carnitine may have potential anticancer effects and inhibits the progression of macroscopic and pre-cancerous tumors and prevents the growth and proliferation of cancerous cells.
