Ali Sadeghi; Hassan Hamedi; Peyman Mahasti Shotorbani; Maryam Fahimdanesh
Volume 1, Issue 3 , September 2018, , Pages 12-16
Abstract
Biodegradable polymeric nanoparticles have been extensively used as colloidal materials for nanoparticles production designed for various purposes, including drug targeting, enhancement of drug bioavailability and protection of drug bioactivity and stability. In particular, poly (lactide‐co‐glycolide) ...
Read More
Biodegradable polymeric nanoparticles have been extensively used as colloidal materials for nanoparticles production designed for various purposes, including drug targeting, enhancement of drug bioavailability and protection of drug bioactivity and stability. In particular, poly (lactide‐co‐glycolide) (PLGA) as a polyester has been FDA approved for human use. In this research, the biodegradable polymeric nanoparticle of casein/poly lactic-co-glycolic acid (PLGA) containing three concentrations of alpha-tocopherol was prepared. The comparative evaluation of these nanoparticles, including morphology, size, zeta potential, entrapment rate, spectroscopy, thermal resistance, and their release profile was carried out. The comparative results suggested that the sizes of derived nanoparticles were between 150 and 350 nanometers. In addition, there was a significant difference between the nanoparticles size and increase in alpha-tocopherol percentage used in this formulation (p<0.05). The accumulated results indicated that the highest entrapment rate belonged to 10 percent of alpha-tocopherol, and higher concentrations decrease the entrapment rate. The using of casein/PLGA can be optimized the characteristics and morphological properties of nanoparticles. The polymeric nanoparticles containing alpha-tocopherol can be used as a biologic preservative to improve drug delivery and consumer health.
Peyman Mahasti Shotorbani; Hassan Hamedi; Melika Zandi; Maryam Fahimdanesh
Volume 1, Issue 1 , March 2018, , Pages 12-18
Abstract
Edible oils can be misdescribed by substituting one ingredient for a similar, but less expensive or over-declaring a quantitative ingredient. Thus, the identification of raw materials in edible oils is important for authentication. In This study, three methods (saponification value, sterol and fatty ...
Read More
Edible oils can be misdescribed by substituting one ingredient for a similar, but less expensive or over-declaring a quantitative ingredient. Thus, the identification of raw materials in edible oils is important for authentication. In This study, three methods (saponification value, sterol and fatty acids analysis) were used to compare for fraud detection in edible oils. Tests used to assess the quality of sesame oil and oils obtained from mixing sesame oil with sunflower and corn oils. The results showed that campesterol, Δ7-avenasterol, Δ5-avenasterol and Δ7-stigmastenol values can be used as detectors for corn oil mixed with sesame oil, even at a concentration of 5%. Also, in the detection of sesame oil fraud, measuring the fatty acids include oleic, linolenic, linoleic and behenic is more suitable even at a concentration of 5% of sunflower oil adding. In general, the best method for detecting of fraud at all concentrations of added sunflower oil was the saponification value method, while fatty acid composition and desmethylsterols composition was suitable for both corn and sunflower oils mixing.
